efficacy of rectal misoprostol for prevention of postpartum hemorrhage
نویسندگان
چکیده
postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. the aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage. this double blind randomized clinical trial was performed on full term pregnant women candidate for vaginal delivery, referred to zahedan imam ali hospital during 2008-2009. they were randomly divided into two groups of rectal misoprostol and oxytocin. the women in misoprostol group received 400 µg rectal misoprostol after delivery and the women in oxytocin group received 3 iu oxytocin in 1 l ringer serum, intravenously. rate of bleeding, need to any surgery interventions, rate of transfusion and changes in hemoglobin and hematocrite were compared between two groups. a total of 400 patients (200 cases in misoprostol group and 200 in oxytocin group) entered to the study. rate of bleeding > 500 cc was significantly higher in oxytocin group than misoprostol group (33% vs. 19%) (p = 0.005). also, need to excessive oxytocin for management of postpartum hemorrhage was significantly lower in misoprostol group than oxytocin group (18% vs. 30%) (p = 0.003). decrease in hematocrite was significantly more observed in oxytocin group than misoprostol group (mean decrease of hematocrite was 1.3 ± 1.6 in misoprostol group and 1.6 ± 2.2 in oxytocin group). two groups were similar in terms of side-effects. rectal misoprostol as an uterotonic drug can decrease postpartum hemorrhage and also can prevent from decrease of hemoglobin as compared to oxytocin.
منابع مشابه
Efficacy of Rectal Misoprostol for Prevention of Postpartum Hemorrhage
Postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. Active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. The aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage. This double blind randomized clinical trial was performed on full term pregnan...
متن کاملEfficacy of Rectal Misoprostol for Prevention of Postpartum Hemorrhage
Postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. Active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. The aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage. This double blind randomized clinical trial was performed on full term pregnan...
متن کاملEfficacy of Rectal Misoprostol for Prevention of Postpartum Hemorrhage
Postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. Active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. The aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage. This double blind randomized clinical trial was performed on full term pregnan...
متن کاملPrevention of postpartum hemorrhage with misoprostol.
As a stable, orally active and cheap uterotonic, misoprostol would appear ideally suited to the prevention of postpartum hemorrhage (PPH) in the developing world. Following numerous clinical trials, it appears that misoprostol prophylaxis using an oral or sublingual dose of 600 microg is more effective than placebo at preventing PPH in community births (relative risk 0.59, 95% confidence interv...
متن کاملSafety and Efficacy of Misoprostol versus Oxytocin for the Prevention of Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the commonest cause of maternal death worldwide. Studies suggest that the use of misoprostol may be beneficial in clinical settings where oxytocin is unavailable. The aim of this study was to compare the safety and efficacy of oxytocin and misoprostol when used in the prevention of PPH. In a double-blind randomized controlled trial, 400 pregnant women who had a va...
متن کاملMisoprostol versus Oxytocin in Prevention of Postpartum Hemorrhage
Study background: The present study was done to compare oxytocin and misoprostol in active management of third stage of labor. Materials and methods: Total of 200 pregnant women were enrolled in the study were divided into two randomized groups. Group ‘A’ included 100 primigravidas with singleton pregnancy and normal vaginal delivery, who received 600μg misoprostol sublingually with delivery of...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۲، شماره ۲، صفحات ۴۶۹-۴۷۴
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